Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21362431 | 0.87 | TDP1 (0.40) | MAPTALDH1A1LMNAHTTNPC1 | |
| SCHEMBL5537953 | 0.73 | TDP1 (0.61) | MAPTAKR1C3ALDH1A1LMNANPC1 | |
| SCHEMBL20158166 | 0.73 | MAPT (0.43) | MAPTAKR1C3ALDH1A1LMNAHTT | |
| SCHEMBL3132601 | 0.73 | AKR1C3 (0.65) | MAPTAKR1C3ALDH1A1LMNAHTT | |
| SCHEMBL20157316 | 0.73 | MAPT (0.61) | MAPTAKR1C3ALDH1A1LMNAHTT | |
| SCHEMBL28770832 | 0.73 | AKR1C3 (0.56) | MAPTAKR1C3ALDH1A1LMNATDP1 | |
| SCHEMBL20157816 | 0.72 | MAPT (0.51) | MAPTAKR1C3ALDH1A1LMNAHTT | |
| SCHEMBL11476383 | 0.72 | MAPT (0.51) | MAPTAKR1C3ALDH1A1LMNAHTT | |
| SCHEMBL20157960 | 0.72 | SRD5A2 (0.49) | MAPTAKR1C3ALDH1A1LMNAHTT | |
| SCHEMBL20157547 | 0.71 | MAPT (0.50) | MAPTAKR1C3ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |