SCHEMBL20157960

SCHEMBL20157960

Cc1ccc(C(=O)c2ccc(CBr)cc2Br)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 2/20 0.49
MAPT P10636 3/20 0.48
ALDH1A1 P00352 2/20 0.46
LMNA P02545 1/20 0.46
HTT P42858 2/20 0.44
NPC1 O15118 2/20 0.44
MAPK1 P28482 1/20 0.44
GSK3B P49841 1/20 0.43
AKR1C3 P42330 1/20 0.42
RAB9A P51151 2/20 0.42
GAA P10253 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
CES2 O00748 2/20 0.41
CES1 P23141 2/20 0.41
RXRA P19793 1/20 0.40
CYP4F2 P78329 1/20 0.39
CYP4A11 Q02928 1/20 0.39
KDM5A P29375 1/20 0.39
THRA P10827 1/20 0.39
THRB P10828 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20157429 0.88 SRD5A2 (0.49) SRD5A2MAPTALDH1A1LMNAHTT
SCHEMBL20157976 0.85 MAPT (0.49) SRD5A2MAPTALDH1A1LMNAHTT
SCHEMBL20157297 0.84 GSK3B (0.43) SRD5A2MAPTALDH1A1MAPK1GSK3B
SCHEMBL20157560 0.84 PTPN1 (0.43) SRD5A2MAPTALDH1A1LMNAHTT
SCHEMBL20157412 0.84 NPC1 (0.54) MAPTALDH1A1LMNAHTTNPC1
SCHEMBL20157951 0.82 MAPT (0.47) SRD5A2MAPTALDH1A1LMNAHTT
SCHEMBL20157342 0.81 SRD5A2 (0.43) SRD5A2MAPTALDH1A1LMNAHTT
SCHEMBL20158073 0.81 LMNA (0.46) MAPTALDH1A1LMNAHTTNPC1
SCHEMBL20157821 0.81 CYP4F2 (0.46) MAPTALDH1A1NPC1RAB9ACYP4F2
SCHEMBL20157772 0.81 LOXL2 (0.38) MAPTALDH1A1LMNAHTTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3539960-A1 NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) 2019-09-18 EP disclosed
WO-2018086605-A1 NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF 山东罗欣药业集团股份有限公司 2018-05-17 WO disclosed