Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | F2RL1 | P55085 | 3/20 | 0.30 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11867787 | 0.75 | HDAC3 (0.36) | KMT2ATHRATHRBBRD4AOC3 | |
| SCHEMBL21362648 | 0.73 | ACHE (0.39) | KMT2ATHRATHRBBRD4CREBBP | |
| SCHEMBL20157454 | 0.72 | ALDH1A1 (0.46) | KMT2AMEN1 | |
| SCHEMBL20157912 | 0.72 | BRD4 (0.32) | KMT2AMEN1THRATHRBBRD4 | |
| SCHEMBL20157878 | 0.72 | CHRNA7 (0.38) | KMT2A | |
| SCHEMBL11857823 | 0.71 | APLNR (0.44) | KMT2AMEN1THRATHRB | |
| SCHEMBL20154947 | 0.68 | EPAS1 (0.45) | BRD4 | |
| SCHEMBL21564724 | 0.67 | HPGD (0.40) | KMT2A | |
| SCHEMBL11853713 | 0.67 | IDO1 (0.41) | KMT2AMEN1 | |
| SCHEMBL21352143 | 0.66 | BRD4 (0.34) | ALOX5KMT2ATHRATHRBBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |