SCHEMBL21363676

SCHEMBL21363676

CC(C)(C)c1cc2c(cc1OCCC(F)(F)F)OCO2

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 1/20 0.45
HTR2A P28223 2/20 0.39
KCNH2 Q12809 2/20 0.33
TMEM97 Q5BJF2 2/20 0.33
SIGMAR1 Q99720 2/20 0.33
LMNA P02545 1/20 0.33
HPGD P15428 1/20 0.33
PDE3B Q13370 1/20 0.32
PDE3A Q14432 1/20 0.32
IGF1R P08069 1/20 0.32
HTT P42858 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
KMT2A Q03164 1/20 0.32
MAOB P27338 2/20 0.31
KDM4E B2RXH2 1/20 0.31
GAA P10253 1/20 0.31
MAPK1 P28482 1/20 0.31
MCHR1 Q99705 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21363680 0.82 SLC6A9 (0.41) SLC6A9KCNH2TMEM97SIGMAR1LMNA
SCHEMBL21363674 0.71 CDK4 (0.44) SLC6A9LMNAHTTL3MBTL1KMT2A
SCHEMBL6364660 0.71 CYP3A4 (0.39) LMNAHPGDKDM4EMAPK1
SCHEMBL21363667 0.70 SLC6A9 (0.36) SLC6A9LMNAHPGDIGF1RKMT2A
SCHEMBL21366553 0.68 SLC6A9 (0.32) SLC6A9HTR2ALMNAHPGDGAA
SCHEMBL11085807 0.67 RAB9A (0.42) SLC6A9LMNAL3MBTL1KMT2AMAOB
SCHEMBL21363665 0.67 NPC1 (0.38) SLC6A9KCNH2TMEM97SIGMAR1L3MBTL1
SCHEMBL11086473 0.66 MAOB (0.42) LMNAHPGDKMT2AMAOBKDM4E
SCHEMBL24008355 0.65 ALDH1A1 (0.40) LMNAHPGDL3MBTL1MAPK1
SCHEMBL11082331 0.65 MAOB (0.38) LMNAHPGDHTTMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019175713-A1 NEW CATECHOL MOLECULES AND THEIR USE AS INHIBITORS TO P450 RELATED METABOLIC PATHWAYS BASF CORPORATION (US) 2019-09-19 WO disclosed
WO-2019175712-A1 NEW USES FOR CATECHOL MOLECULES AS INHIBITORS TO GLUTATHIONE S-TRANSFERASE METABOLIC PATHWAYS BASF CORPORATION (US) 2019-09-19 WO disclosed