Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15637908 | 0.89 | EGLN2 (0.38) | EGLN2EGFRKDRTGFBR1HSD11B1 | |
| SCHEMBL21363870 | 0.85 | TGFBR1 (0.40) | EGLN2EGFRKDRTGFBR1TSHR | |
| SCHEMBL15639204 | 0.84 | TGFBR1 (0.42) | EGLN2TGFBR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21363871 | 0.82 | EGLN2 (0.43) | EGLN2KDRTGFBR1MAP4K4 | |
| SCHEMBL21363867 | 0.82 | KMO (0.39) | EGLN2EGFRKDRTGFBR1MAP4K4 | |
| SCHEMBL15639419 | 0.81 | TGFBR1 (0.39) | EGLN2EGFRKDRTGFBR1GABRG2 | |
| SCHEMBL15638231 | 0.81 | TGFBR1 (0.47) | EGLN2TGFBR1HSD11B1GABRG2GABRB3 | |
| SCHEMBL15639873 | 0.79 | PDE4A (0.37) | EGLN2EGFRKDRTGFBR1SLC6A2 | |
| SCHEMBL15639331 | 0.77 | MAP4K4 (0.39) | EGLN2EGFRKDRTGFBR1GABRG2 | |
| SCHEMBL15637370 | 0.76 | EGLN2 (0.49) | EGLN2TGFBR1HSD11B1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190284155-A1 | 2,3-Disubstituted Pyridine Compounds as TGF-Beta Inhibitors and Methods of Use | RIGEL PHARMACEUTICALS, INC. (US) | 2019-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190284155-A1 | 2,3-Disubstituted Pyridine Compounds as TGF-Beta Inhibitors and Methods of Use | TGFBR2, ACVR1, TGFBR1 | EGLN2 657/4885EGFR 41/4885KDR 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.