Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.43 |
| ▸ | RORB | Q92753 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15639472 | 0.88 | EGLN2 (0.41) | EGLN2RORBMAP4K4JAK2NPC1 | |
| SCHEMBL21363870 | 0.86 | TGFBR1 (0.40) | EGLN2KDRTGFBR1 | |
| SCHEMBL15639999 | 0.84 | TGFBR1 (0.46) | EGLN2RORBMAP4K4JAK2NPC1 | |
| SCHEMBL21363867 | 0.83 | KMO (0.39) | EGLN2MAP4K4JAK2KDRTGFBR1 | |
| SCHEMBL21363868 | 0.82 | EGLN2 (0.39) | EGLN2MAP4K4KDRTGFBR1 | |
| SCHEMBL15640085 | 0.82 | EGLN2 (0.44) | EGLN2RORBMAP4K4JAK2NPC1 | |
| SCHEMBL15638698 | 0.81 | RORB (0.43) | RORBJAK2KCNA5PTGER1KCNN4 | |
| SCHEMBL15638088 | 0.77 | TGFBR1 (0.40) | KDRTGFBR1PDE4APDE4BPDE4C | |
| SCHEMBL15638994 | 0.75 | EGLN2 (0.51) | EGLN2RORBJAK2KCNA5PTGER1 | |
| SCHEMBL15639882 | 0.74 | KDR (0.43) | EGLN2RORBMAP4K4JAK2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190284155-A1 | 2,3-Disubstituted Pyridine Compounds as TGF-Beta Inhibitors and Methods of Use | RIGEL PHARMACEUTICALS, INC. (US) | 2019-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190284155-A1 | 2,3-Disubstituted Pyridine Compounds as TGF-Beta Inhibitors and Methods of Use | TGFBR2, ACVR1, TGFBR1 | EGLN2 657/4885RORB 786/4885MAP4K4 945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.