Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 13/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15184285 | 0.93 | TSHR (0.46) | TSHRRECQLAGTR2HCRTR1HCRTR2 | |
| SCHEMBL16277323 | 0.93 | TSHR (0.46) | TSHRRECQLAGTR2HCRTR1HCRTR2 | |
| SCHEMBL16277356 | 0.82 | TSHR (0.48) | TSHRRECQLAGTR2HCRTR1HCRTR2 | |
| SCHEMBL15184249 | 0.82 | TSHR (0.48) | TSHRRECQLAGTR2HCRTR1HCRTR2 | |
| SCHEMBL2136577 | 0.81 | AGTR2 (0.47) | TSHRRECQLAGTR2HCRTR1HCRTR2 | |
| SCHEMBL2132411 | 0.77 | HSD11B1 (0.43) | HCRTR1HCRTR2LMNA | |
| SCHEMBL983877 | 0.75 | KDM4E (0.46) | HCRTR1HCRTR2LMNA | |
| SCHEMBL2930541 | 0.74 | HCRTR1 (0.46) | TSHRRECQLHCRTR1HCRTR2 | |
| SCHEMBL3415643 | 0.74 | HCRTR1 (0.46) | TSHRRECQLHCRTR1HCRTR2 | |
| SCHEMBL2128177 | 0.74 | HCRTR1 (0.56) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236801-B2 | 2-aza-bicyclo[2.2.1]heptane derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-08-07 | — | — | US | claimed |
| EP-2247586-B1 | 2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-04-25 | — | — | EP | claimed |
| US-8236801-B2 | 2-aza-bicyclo[2.2.1]heptane derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-08-07 | — | — | US | disclosed |