Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | PGK1 | P00558 | 2/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7730804 | 0.96 | ACE2 (0.48) | ACE2KDM1APRMT6CYP2C19MEN1 | |
| SCHEMBL19071988 | 0.93 | ACE2 (0.56) | ACE2KDM1APRMT6CYP2C19MEN1 | |
| SCHEMBL4395015 | 0.89 | ACE2 (0.61) | ACE2KDM1APRMT6CARM1PRMT8 | |
| SCHEMBL4783223 | 0.89 | ACE2 (0.54) | ACE2KDM1APRMT6CYP2C19MEN1 | |
| SCHEMBL13660816 | 0.88 | PRMT6 (0.43) | ACE2KDM1APRMT6CARM1PRMT8 | |
| SCHEMBL16504283 | 0.87 | ACE2 (0.50) | ACE2KDM1APRMT6CYP2C19MEN1 | |
| SCHEMBL13008045 | 0.87 | ACE2 (0.50) | ACE2KDM1APRMT6CYP2C19MEN1 | |
| SCHEMBL22416389 | 0.84 | ACE2 (0.52) | ACE2KDM1APRMT6CARM1PRMT8 | |
| SCHEMBL14980630 | 0.83 | ACE2 (0.63) | ACE2KDM1APRMT6CYP2C19MEN1 | |
| SCHEMBL16920253 | 0.83 | ACE2 (0.76) | ACE2PRMT6CYP2C19MEN1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019177902-A1 | MODULATORS OF BTK PROTEOLYSIS AND METHODS OF USE | YALE UNIVERSITY (US) | 2019-09-19 | — | — | WO | disclosed |