Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1272627 | 0.78 | KDM4E (0.42) | IRAK4ALDH1A1KDM4EALOX15 | |
| SCHEMBL21372227 | 0.76 | KDM4E (0.36) | ALDH1A1KDM4EALOX15 | |
| SCHEMBL24854184 | 0.76 | ATM (0.32) | IRAK4 | |
| SCHEMBL20635764 | 0.75 | APLNR (0.35) | — | |
| SCHEMBL24311028 | 0.75 | JAK2 (0.36) | IRAK4 | |
| SCHEMBL8318850 | 0.70 | — | — | |
| SCHEMBL20457992 | 0.70 | JAK1 (0.32) | — | |
| SCHEMBL28642774 | 0.70 | CTSL (0.30) | ACHE | |
| SCHEMBL5151012 | 0.70 | KDM4E (0.33) | ALDH1A1KDM4EALOX15 | |
| SCHEMBL20715341 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180344-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES USEFUL FOR INHIBITING JANUS KINASE | PFIZER (US) | 2019-09-18 | — | — | EP | disclosed |