Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21371985 | 0.76 | IRAK4 (0.42) | KDM4EALDH1A1ALOX15 | |
| SCHEMBL16488092 | 0.73 | — | — | |
| SCHEMBL2051129 | 0.72 | — | — | |
| SCHEMBL20635764 | 0.71 | APLNR (0.35) | — | |
| SCHEMBL24311028 | 0.71 | JAK2 (0.36) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL20635094 | 0.69 | SMN1; SMN2 (0.42) | KDM4EALDH1A1ALOX15POLB | |
| SCHEMBL17930578 | 0.68 | — | — | |
| SCHEMBL14966497 | 0.67 | — | — | |
| SCHEMBL776888 | 0.67 | MMP1 (0.33) | KDM4EALDH1A1 | |
| SCHEMBL28838041 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180344-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES USEFUL FOR INHIBITING JANUS KINASE | PFIZER (US) | 2019-09-18 | — | — | EP | disclosed |