Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Guanazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanazole SCHEMBL15697 | 0.84 | — | — | |
| Guanazole SCHEMBL16014610 | 0.82 | — | — | |
| Guanazole SCHEMBL31753920 | 0.82 | — | — | |
| Guanazole SCHEMBL6030091 | 0.81 | ALDH1A1 (0.36) | ALDH1A1KDM4EMEN1CYP1A2KMT2A | |
| Guanazole SCHEMBL9530322 | 0.80 | ALDH1A1 (0.39) | ALDH1A1KDM4EMEN1CYP1A2KMT2A | |
| Phosphoric Acid SCHEMBL407305 | 0.70 | CYP1A2 (0.42) | CYP1A2 | |
| Phosphoric Acid SCHEMBL73239 | 0.70 | CYP1A2 (0.42) | CYP1A2 | |
| Phosphoric Acid SCHEMBL670321 | 0.70 | CYP1A2 (0.42) | CYP1A2 | |
| Phosphoric Acid SCHEMBL752823 | 0.70 | CYP1A2 (0.42) | CYP1A2 | |
| Phosphoric Acid SCHEMBL10873614 | 0.70 | CYP1A2 (0.42) | CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235604-B2 | Polyamide- and polyolefin-based fire-retarded compositions | ATOFINA (FR) | 2007-06-26 | — | — | US | claimed |
| EP-1375594-B1 | Flame retardant compositions based on polyamide and polyolefine | ARKEMA (FR) | 2005-12-14 | — | — | EP | claimed |
| US-20040054054-A1 | Polyamide-and polyolefin-based fire-retarded compositions | ANTOFINA (FR) | 2004-03-18 | — | — | US | claimed |
| US-12018140-B2 | Flexible fire-retardant thermoplastic compositions having high thermomechanical strength, in particular for electric cables | SK GEO CENTRIC CO., LTD. (KR) | 2024-06-25 | — | — | US | disclosed |
| CN-105593340-B | Flexible flameproof thermoplastic composition with high thermomechanical strength, in particular for electric cables | 阿肯马法国公司 | 2020-11-03 | — | — | CN | disclosed |
| US-20160185942-A1 | FLEXIBLE FIRE-RETARDANT THERMOPLASTIC COMPOSITIONS HAVING HIGH THERMOMECHANICAL STRENGTH, IN PARTICULAR FOR ELECTRIC CABLES | ARKEMA FRANCE (FR) | 2016-06-30 | — | — | US | disclosed |
| CN-105593340-A | Flexible flameproof thermoplastic composition with high thermomechanical strength, in particular for electric cables | ARKEMA FRANCE | 2016-05-18 | — | — | CN | disclosed |
| US-8076406-B2 | Composite based on polylactic acid and a polyamide, having improved impact strength, and its manufacturing process and use | ARKEMA FRANCE (FR) | 2011-12-13 | — | — | US | disclosed |
| CN-101495567-B | Composite based on polylactic acid and a polyamide, having improved impact resistance, its manufacturing process and use | TEKNIMED | 2011-07-20 | — | — | CN | disclosed |
| US-7897673-B2 | Flexible high thermomechanical stress-resistant and fireproof halogen-free thermoplastic compositions | ARKEMA FRANCE (FR) | 2011-03-01 | — | — | US | disclosed |
| US-20100113677-A1 | COMPOSITE BASED ON POLYLACTIC ACID AND A POLYAMIDE, HAVING IMPROVED IMPACT RESISTANCE, ITS MANUFACTURING PROCESS AND USE | ARKEMA FRANCE (FR) | 2010-05-06 | — | — | US | disclosed |
| US-20090253836-A1 | FLEXIBLE HIGH THERMOMECHANICAL STRESS-RESISTANT AND FIREPROOF HALOGEN-FREE THERMOPLASTIC COMPOSITIONS | ARKEMA FRANCE (FR) | 2009-10-08 | — | — | US | disclosed |
| CN-101495567-A | Composite based on polylactic acid and a polyamide, having improved impact resistance, its manufacturing process and use | ARKEMA FRANCE (FR) | 2009-07-29 | — | — | CN | disclosed |
| US-7235604-B2 | Polyamide- and polyolefin-based fire-retarded compositions | ATOFINA (FR) | 2007-06-26 | — | — | US | disclosed |
| US-20040054054-A1 | Polyamide-and polyolefin-based fire-retarded compositions | ANTOFINA (FR) | 2004-03-18 | — | — | US | disclosed |