Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Guanazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanazole SCHEMBL31753920 | 0.82 | — | — | |
| Sulfuric Acid SCHEMBL170855 | 0.76 | ALDH1A1 (0.33) | ALDH1A1KDM4EMEN1CYP1A2KMT2A | |
| SCHEMBL9168300 | 0.74 | — | — | |
| Guanazole SCHEMBL508394 | 0.74 | ALDH1A1 (0.33) | ALDH1A1KDM4EMEN1CYP1A2KMT2A | |
| Sulfuric Acid SCHEMBL129071 | 0.70 | CA5A (0.43) | ALDH1A1KDM4EMEN1CYP1A2KMT2A | |
| Sulfuric Acid SCHEMBL3338642 | 0.70 | CA5A (0.43) | ALDH1A1KDM4EMEN1CYP1A2KMT2A | |
| Sulfuric Acid SCHEMBL3344978 | 0.70 | CA5A (0.43) | ALDH1A1KDM4EMEN1CYP1A2KMT2A | |
| Sulfuric Acid SCHEMBL11529048 | 0.68 | CA5A (0.40) | ALDH1A1KDM4EMEN1CYP1A2KMT2A | |
| Sulfuric Acid SCHEMBL11564899 | 0.68 | CA5A (0.40) | ALDH1A1KDM4EMEN1CYP1A2KMT2A | |
| Sulfuric Acid SCHEMBL27603434 | 0.67 | KDM4E (0.42) | KDM4ECYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992138-B2 | Polyurethane polymer | KANEKA CORPORATION (JP) | 2006-01-31 | — | — | US | disclosed |
| US-20040171765-A1 | Polyurethane polymer | KANEKA CORPORATION (JP) | 2004-09-02 | — | — | US | disclosed |