SCHEMBL2138102

SCHEMBL2138102

C=C(C)C(=O)OCCOCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C

nearest known ligand 0.51

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.51
TSHR P16473 6/20 0.42
ALDH1A1 P00352 4/20 0.35
POLB P06746 1/20 0.34
APEX1 P27695 1/20 0.34
HTT P42858 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
TP53 P04637 2/20 0.33
HIF1A Q16665 2/20 0.33
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14278963 1.00 THRB (0.51) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL2367369 0.96 THRB (0.47) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL10661639 0.94 THRB (0.46) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL14278962 0.94 TSHR (0.46) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL10890327 0.93 THRB (0.45) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL2367301 0.93 THRB (0.47) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL35807 0.91 TSHR (0.51) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL18176157 0.90 THRB (0.42) THRBTSHR
SCHEMBL333002 0.89 TSHR (0.50) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL12396078 0.88 THRB (0.51) THRBTSHRALDH1A1POLBAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3861039-B1 HYDROGEL COMPOSITIONS OPHTALMIC CIE (FR) 2023-11-01 EP claimed
US-8492513-B2 Method for enhancing water content of silicone hydrogel contact lens FAR EASTERN NEW CENTURY CORPORATION (TW) 2013-07-23 US claimed
US-20120214899-A1 METHOD FOR ENHANCING WATER CONTENT OF SILICONE HYDROGEL CONTACT LENS FAR EASTERN NEW CENTURY CORPORATION (TW) 2012-08-23 US claimed
US-20120214898-A1 SILICONE HYDROGEL WITH HIGH WATER CONTENT FAR EASTERN NEW CENTURY CORPORATION (TW) 2012-08-23 US claimed
US-7906563-B2 Polysiloxane-based prepolymer and hydrogel FAR EASTERN NEW CENTURY CORPORATION (TW) 2011-03-15 US claimed
US-20090170976-A1 Polysiloxane-based prepolymer and hydrogel FAR EASTERN TEXTILE LTD. 2009-07-02 US claimed
JP-60131518-A None JP disclosed
US-12492294-B2 Biocompatible porous materials and methods of manufacture and use Poragen LLC (US) 2025-12-09 US disclosed
US-12116468-B2 Composite particles comprising a hydrophobic dye and an amphiphilic block copolymer and use thereof in optical applications COLOURSMITH LABS INC. (CA) 2024-10-15 US disclosed
US-20240034853-A1 BIOCOMPATIBLE POROUS MATERIALS AND METHODS OF MANUFACTURE AND USE Renovo Concepts, Inc. 2024-02-01 US disclosed
EP-3861039-B1 HYDROGEL COMPOSITIONS OPHTALMIC CIE (FR) 2023-11-01 EP disclosed
US-11692075-B2 Biocompatible porous materials and methods of manufacture and use Poragen LLC (US) 2023-07-04 US disclosed
EP-4125734-A1 BIOCOMPATIBLE POROUS MATERIALS AND METHODS OF MANUFACTURE AND USE Poragen LLC (US) 2023-02-08 EP disclosed
US-6867245-B2 Long wearable soft contact lens ASAHIKASEI AIME CO., LTD. (JP) 2005-03-15 US disclosed
US-20040192872-A1 Long-wearable soft contact lens ASAHIKASEI AIME CO., LTD (JP) 2004-09-30 US disclosed
EP-1243960-A1 SOFT CONTACT LENS CAPABLE OF BEING WORN FOR A LONG PERIOD ASAHIKASEI AIME CO., Ltd. (JP) 2002-09-25 EP disclosed
US-20020016383-A1 Long wearable soft contact lens COOPERVISION INTERNATIONAL LIMITED (GB) 2002-02-07 US disclosed
US-6286955-B1 CONTACT LENSES IN WHICH ALKOXYALKYL (METH)ACRYLATE (CO)POLYMER LAYER IS FORMED ON THE SURFACE OF THE LENS; FREE FROM ADHESION AND EASILY CLEANED OF LIPID AND PROTEINS IN TEARS Sakai, Tetsuya (JP) 2001-09-11 US disclosed
US-4602074-A SILICON CONTAINING ACRYLIC MONOMER NIPPON CONTACT LENS MANUFACTURING LTD. (JP) 1986-07-22 US disclosed
JP-S60131518-A CONTACT LENS MATERIAL NIPPON CONTACT LENS SEIZO KK 1985-07-13 JP disclosed