Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21381489 | 0.87 | KDM4E (0.50) | SMN1; SMN2LMNAFAAHCMA1ALDH1A1 | |
| SCHEMBL20379138 | 0.85 | MAPT (0.49) | SMN1; SMN2LMNACMA1TP53ALDH1A1 | |
| SCHEMBL21382022 | 0.85 | CMA1 (0.44) | SMN1; SMN2FAAHCMA1ALDH1A1PKM | |
| SCHEMBL20379142 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNACMA1TP53ALDH1A1 | |
| SCHEMBL21381493 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNACMA1ALDH1A1HTT | |
| SCHEMBL20379164 | 0.82 | TRPV6 (0.47) | SMN1; SMN2LMNACMA1ALDH1A1PKM | |
| SCHEMBL28331553 | 0.81 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAFAAHCMA1SCN9A | |
| SCHEMBL21373574 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAFAAHCMA1TP53 | |
| SCHEMBL21373517 | 0.78 | MAP2K4 (0.40) | SMN1; SMN2LMNAFAAHCMA1MAP2K4 | |
| SCHEMBL28331433 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAFAAHCMA1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768673-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH Zurich (CH) | 2021-01-27 | — | — | EP | claimed |
| WO-2019179890-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH ZURICH (CH) | 2019-09-26 | — | — | WO | claimed |
| CN-116462666-A | Cytoprotective compounds and uses thereof | 瑞士苏黎世联邦理工学院 | 2023-07-21 | — | — | CN | disclosed |
| EP-3768673-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH Zurich (CH) | 2021-01-27 | — | — | EP | disclosed |
| WO-2019179890-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH ZURICH (CH) | 2019-09-26 | — | — | WO | disclosed |