Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21381489 | 0.88 | KDM4E (0.50) | SMN1; SMN2KMT2AGAACMA1ALDH1A1 | |
| SCHEMBL20379142 | 0.88 | SMN1; SMN2 (0.49) | SMN1; SMN2TSHRPKMKMT2AGAA | |
| SCHEMBL21382022 | 0.88 | CMA1 (0.44) | SMN1; SMN2TSHRPKMKMT2ACMA1 | |
| SCHEMBL20379138 | 0.88 | MAPT (0.49) | SMN1; SMN2TSHRPKMGAACMA1 | |
| SCHEMBL21381467 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2TSHRPKMKMT2ACMA1 | |
| SCHEMBL20379164 | 0.84 | TRPV6 (0.47) | SMN1; SMN2TSHRPKMKMT2ACMA1 | |
| SCHEMBL28331427 | 0.80 | ALDH1A1 (0.51) | SMN1; SMN2TSHRPKMKMT2AGAA | |
| SCHEMBL21373634 | 0.79 | CMA1 (0.50) | SMN1; SMN2TSHRPKMKMT2ACMA1 | |
| SCHEMBL21381476 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2TSHRPKMKMT2AGAA | |
| SCHEMBL21373590 | 0.75 | CMA1 (0.47) | SMN1; SMN2TSHRPKMKMT2ACMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768673-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH Zurich (CH) | 2021-01-27 | — | — | EP | claimed |
| WO-2019179890-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH ZURICH (CH) | 2019-09-26 | — | — | WO | claimed |
| EP-3768673-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH Zurich (CH) | 2021-01-27 | — | — | EP | disclosed |
| WO-2019179890-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH ZURICH (CH) | 2019-09-26 | — | — | WO | disclosed |