Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 6/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213605 | 0.99 | KDM4E (0.46) | KDM4EALDH1A1NOTUMPPARALTB4R | |
| SCHEMBL215046 | 0.96 | ALDH1A1 (0.48) | KDM4EALDH1A1NOTUMPPARALTB4R | |
| SCHEMBL213815 | 0.86 | ABL1 (0.41) | LTB4REGLN1CYSLTR2CYSLTR1 | |
| SCHEMBL213675 | 0.85 | NOTUM (0.49) | KDM4EALDH1A1NOTUMWNT3ACHEK1 | |
| SCHEMBL2837602 | 0.84 | NOTUM (0.46) | KDM4EALDH1A1NOTUMPPARAWNT3A | |
| SCHEMBL213202 | 0.82 | NOTUM (0.46) | KDM4EALDH1A1NOTUMWNT3ACHEK1 | |
| SCHEMBL212870 | 0.82 | NOTUM (0.46) | KDM4EALDH1A1NOTUMWNT3ACHEK1 | |
| SCHEMBL2841379 | 0.80 | CTSK (0.43) | KDM4EALDH1A1NOTUMEGLN1WNT3A | |
| SCHEMBL214063 | 0.79 | NOTUM (0.47) | KDM4EALDH1A1NOTUMWNT3ACHEK1 | |
| SCHEMBL15482046 | 0.77 | KDM4E (0.61) | KDM4EALDH1A1NOTUMEGLN1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |