Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | LIPC | P11150 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27357767 | 0.81 | GAA (0.44) | LMNAPOLBSMN1; SMN2GAATHRB | |
| SCHEMBL1971626 | 0.81 | ITGB3 (0.45) | SMN1; SMN2ITGB3ITGA2BGAATHRB | |
| SCHEMBL22835340 | 0.81 | ITGB3 (0.45) | SMN1; SMN2ITGB3ITGA2BGAATHRB | |
| SCHEMBL1967730 | 0.81 | PRMT5 (0.44) | ITGB3ITGA2BALDH1A1PIK3CDGPR119 | |
| SCHEMBL1980890 | 0.81 | PRMT5 (0.44) | ITGB3ITGA2BALDH1A1PIK3CDGPR119 | |
| SCHEMBL1975644 | 0.81 | PRMT5 (0.44) | ITGB3ITGA2BALDH1A1PIK3CDGPR119 | |
| SCHEMBL3708900 | 0.78 | LMNA (0.54) | LMNAPOLBSMN1; SMN2GAATHRB | |
| SCHEMBL3652388 | 0.78 | LMNA (0.54) | LMNAPOLBSMN1; SMN2GAATHRB | |
| SCHEMBL3652385 | 0.78 | LMNA (0.54) | LMNAPOLBSMN1; SMN2GAATHRB | |
| SCHEMBL2360585 | 0.76 | SMN1; SMN2 (0.47) | LMNAPOLBSMN1; SMN2GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768660-A1 | MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 | Denali Therapeutics Inc. (US) | 2021-01-27 | — | — | EP | disclosed |
| WO-2019183589-A1 | MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 | DENALI THERAPEUTICS INC. (US) | 2019-09-26 | — | — | WO | disclosed |