Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | ATF4 | P18848 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29911480 | 0.79 | RAB9A (0.60) | RAB9ANPC1DAOTDP1L3MBTL1 | |
| SCHEMBL20721952 | 0.76 | HRH3 (0.39) | RAB9AHRH3GPR84MAPTPOLB | |
| SCHEMBL30046670 | 0.72 | HRH3 (0.40) | RAB9ANPC1HRH3GPR84MAPT | |
| SCHEMBL4829470 | 0.72 | GAA (0.47) | RAB9ANPC1TLR8MAPTTDP1 | |
| SCHEMBL18404750 | 0.72 | RAB9A (0.51) | RAB9ANPC1TLR8MAPTPOLB | |
| SCHEMBL19556361 | 0.69 | ATF4 (0.43) | RAB9AHRH3GPR84MAPTTDP1 | |
| SCHEMBL15474265 | 0.69 | NPC1 (0.46) | RAB9ANPC1TLR8MAPTPOLB | |
| SCHEMBL28514514 | 0.68 | GPR84 (0.50) | HRH3GPR84L3MBTL1ATF4PPARG | |
| SCHEMBL21384383 | 0.68 | HRH3 (0.38) | HRH3GPR84TDP1VCPATF4 | |
| SCHEMBL25961308 | 0.68 | HRH3 (0.38) | HRH3TDP1VCPTSHRATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768660-A1 | MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 | Denali Therapeutics Inc. (US) | 2021-01-27 | — | — | EP | disclosed |
| WO-2019183589-A1 | MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 | DENALI THERAPEUTICS INC. (US) | 2019-09-26 | — | — | WO | disclosed |