SCHEMBL21384511

SCHEMBL21384511

O=C(COc1ccc(Cl)c(F)c1)NC1CCNCC1

nearest known ligand 0.71

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ATF4 P18848 16/20 0.71
LMNA P02545 1/20 0.55
RAB9A P51151 2/20 0.52
HPGD P15428 1/20 0.52
HTT P42858 1/20 0.52
NPC1 O15118 1/20 0.50
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL23294544 0.99 ATF4 (0.69) ATF4LMNARAB9AHPGDHTT
SCHEMBL23702451 0.96 ATF4 (0.66) ATF4LMNARAB9AHPGDHTT
Trifluoroacetic Acid SCHEMBL21819336 0.94 ATF4 (0.63) ATF4LMNARAB9AHPGDHTT
SCHEMBL16082976 0.91 ATF4 (0.78) ATF4LMNARAB9AHPGDHTT
SCHEMBL19692630 0.89 ATF4 (0.59) ATF4LMNARAB9AHPGDHTT
SCHEMBL21384520 0.88 ATF4 (0.67) ATF4LMNA
SCHEMBL19134205 0.88 ATF4 (0.73) ATF4LMNARAB9AHPGDNPC1
Hydrochloric Acid SCHEMBL19692616 0.88 ATF4 (0.58) ATF4LMNARAB9AHPGDHTT
SCHEMBL22614154 0.87 ATF4 (0.72) ATF4LMNARAB9AHPGDHTT
SCHEMBL21050157 0.87 ATF4 (0.72) ATF4LMNARAB9AHPGDHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114980894-B Modulators of integrated stress response pathways 埃沃特克国际有限责任公司 2024-10-18 CN disclosed
US-20240140919-A1 MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 DENALI THERAPEUTICS INC. 2024-05-02 US disclosed
US-20230250072-A1 MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 DENALI THERAPEUTICS INC. 2023-08-10 US disclosed
US-20230250072-A1 MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 DENALI THERAPEUTICS INC. 2023-08-10 US disclosed
US-20230250072-A1 MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 DENALI THERAPEUTICS INC. 2023-08-10 US disclosed
US-20230125481-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY EVOTEC INTERNATIONAL GMBH (DE) 2023-04-27 US disclosed
US-20230125481-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY EVOTEC INTERNATIONAL GMBH (DE) 2023-04-27 US disclosed
US-20230125481-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY EVOTEC INTERNATIONAL GMBH (DE) 2023-04-27 US disclosed
EP-4096665-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY Evotec International GmbH (DE) 2022-12-07 EP disclosed
CN-114980894-A Modulators of integrated stress response pathways 埃沃特克国际有限责任公司 2022-08-30 CN disclosed
US-11166942-B2 Inhibitors of integrated stress response pathway Praxis Biotech LLC (US) 2021-11-09 US disclosed
WO-2021151865-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY EVOTEC INTERNATIONAL GMBH (DE) 2021-08-05 WO disclosed
WO-2021151865-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY EVOTEC INTERNATIONAL GMBH (DE) 2021-08-05 WO disclosed
US-20210130308-A1 MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 DENALI THERAPEUTICS INC. 2021-05-06 US disclosed
US-20210130308-A1 MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 DENALI THERAPEUTICS INC. 2021-05-06 US disclosed
EP-3768660-A1 MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 Denali Therapeutics Inc. (US) 2021-01-27 EP disclosed
US-20200101047-A1 INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY Praxis Biotech LLC 2020-04-02 US disclosed
WO-2019183589-A1 MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 DENALI THERAPEUTICS INC. (US) 2019-09-26 WO disclosed
WO-2019183589-A1 MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 DENALI THERAPEUTICS INC. (US) 2019-09-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230250072-A1 MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 EIF2A, EIF4A2, EIF4EBP1 ATF4 118/4885LMNA 3077/4885RAB9A 1780/4885
US-11166942-B2 Inhibitors of integrated stress response pathway ATF4, DDIT3, ATF1 ATF4 1/4885LMNA 4459/4885RAB9A 3893/4885
US-20210130308-A1 MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 EIF2A, EIF4A2, EIF4EBP1 ATF4 118/4885LMNA 3077/4885RAB9A 1780/4885
US-20200101047-A1 INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY ATF4, DDIT3, ATF1 ATF4 1/4885LMNA 4459/4885RAB9A 3893/4885
US-20230125481-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY CRHR2, CRHR1, CRH ATF4 11/4885LMNA 2457/4885RAB9A 2381/4885
US-20240140919-A1 MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 EIF2A, EIF4A2, EIF4EBP1 ATF4 118/4885LMNA 3077/4885RAB9A 1780/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.