SCHEMBL21384541

SCHEMBL21384541

COC(=O)c1cc(Cl)ccc1S(=O)(=O)C1CC1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 1/20 0.48
SLC6A3 Q01959 5/20 0.44
NR4A2 P43354 2/20 0.43
CDK1 P06493 1/20 0.43
SLC6A4 P31645 1/20 0.42
MRGPRX1 Q96LB2 1/20 0.40
ACLY P53396 1/20 0.40
HCRTR1 O43613 1/20 0.40
HCRTR2 O43614 1/20 0.40
FLT1 P17948 1/20 0.40
FLT4 P35916 1/20 0.40
KDR P35968 1/20 0.40
MEN1 O00255 1/20 0.39
LMNA P02545 1/20 0.39
MAPT P10636 1/20 0.39
HTT P42858 1/20 0.39
KMT2A Q03164 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
KDM4E B2RXH2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21384605 0.82 ALDH1A1 (0.49) ACLYKDM4EALDH1A1HPGDCASP1
SCHEMBL17078006 0.80 TRPV4 (0.56) ABL1SLC6A3NR4A2CDK1SLC6A4
SCHEMBL1017485 0.80 ABL1 (0.54) ABL1SLC6A3NR4A2CDK1SLC6A4
SCHEMBL22827732 0.79 CA2 (0.61) ABL1SLC6A3NR4A2CDK1SLC6A4
SCHEMBL21384614 0.79 MRGPRX1 (0.57) ABL1SLC6A3MRGPRX1ACLY
SCHEMBL22827917 0.78 ABL1 (0.51) ABL1SLC6A3NR4A2CDK1SLC6A4
SCHEMBL19437639 0.78 ABL1 (0.51) ABL1SLC6A3NR4A2CDK1SLC6A4
SCHEMBL1015878 0.74 CA1 (0.58) MEN1LMNAKMT2ANPSR1KDM4E
SCHEMBL4599910 0.74 CA1 (0.58) MEN1LMNAKMT2ANPSR1KDM4E
SCHEMBL9766751 0.73 ABL1 (0.47) ABL1SLC6A3NR4A2CDK1SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019179436-A1 ACID AMIDE COMPOUND AND USE THEREOF IN TREATMENT OF CANCERS 成都海创药业有限公司 2019-09-26 WO disclosed