SCHEMBL21384590

SCHEMBL21384590

O=C(O)c1cc(Cl)c(F)cc1NS(=O)(=O)C1CC1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ACLY P53396 2/20 0.48
SCN9A Q15858 5/20 0.41
MRGPRX1 Q96LB2 2/20 0.40
SLC6A2 P23975 1/20 0.39
SLC6A4 P31645 1/20 0.39
SLC6A3 Q01959 1/20 0.39
EGLN1 Q9GZT9 1/20 0.39
CISD1 Q9NZ45 1/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA3 P07451 1/20 0.39
CA4 P22748 1/20 0.39
CA6 P23280 1/20 0.39
CA7 P43166 1/20 0.39
CA9 Q16790 1/20 0.39
CA13 Q8N1Q1 1/20 0.39
CA14 Q9ULX7 1/20 0.39
CA5B Q9Y2D0 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21384566 0.85 MRGPRX1 (0.42) SCN9AMRGPRX1
SCHEMBL21384569 0.83 ACLY (0.48) ACLYMRGPRX1
SCHEMBL15313149 0.82 SLC6A2 (0.45) ACLYSLC6A2SLC6A4SLC6A3CISD1
SCHEMBL21381491 0.78 ACLY (0.61) ACLYMRGPRX1
SCHEMBL15847893 0.77 ACLY (0.60) ACLYMRGPRX1
SCHEMBL4514005 0.77 CA1 (0.51) CISD1CA12CA1CA2CA3
SCHEMBL21394560 0.76 MRGPRX1 (0.51) MRGPRX1CA12CA1CA2CA9
SCHEMBL21381356 0.76 ACLY (0.42) ACLYSCN9AMRGPRX1
SCHEMBL16448625 0.74 SCN9A (0.62) SCN9A
SCHEMBL21381362 0.73 ACLY (0.43) ACLYMRGPRX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019179436-A1 ACID AMIDE COMPOUND AND USE THEREOF IN TREATMENT OF CANCERS 成都海创药业有限公司 2019-09-26 WO disclosed
WO-2019179436-A1 ACID AMIDE COMPOUND AND USE THEREOF IN TREATMENT OF CANCERS 成都海创药业有限公司 2019-09-26 WO disclosed