SCHEMBL2138512

SCHEMBL2138512

CCOC(=O)/C(C#N)=C/c1ccc(OC)c(Cl)c1

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 11/20 0.80
HTT P42858 2/20 0.80
PKM P14618 1/20 0.80
MAPT P10636 8/20 0.72
KMT2A Q03164 6/20 0.72
MEN1 O00255 4/20 0.72
HPGD P15428 5/20 0.59
KDM4E B2RXH2 5/20 0.59
NPSR1 Q6W5P4 2/20 0.59
RXFP1 Q9HBX9 2/20 0.59
PDCD1 Q15116 1/20 0.58
CD274 Q9NZQ7 1/20 0.58
CRHBP P24387 1/20 0.58
CRHR2 Q13324 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.56
CYP3A4 P08684 1/20 0.56
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
CYP1A2 P05177 1/20 0.54
PTP4A1 Q93096 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2138516 1.00 ALDH1A1 (0.80) ALDH1A1HTTPKMMAPTKMT2A
SCHEMBL8364474 0.89 ALDH1A1 (1.00) ALDH1A1HTTPKMMAPTKMT2A
SCHEMBL22259791 0.89 ALDH1A1 (1.00) ALDH1A1HTTPKMMAPTKMT2A
SCHEMBL3610679 0.87 ALDH1A1 (0.67) ALDH1A1HTTPKMMAPTKMT2A
SCHEMBL3610678 0.87 ALDH1A1 (0.67) ALDH1A1HTTPKMMAPTKMT2A
SCHEMBL15082797 0.87 ALDH1A1 (0.67) ALDH1A1HTTPKMMAPTKMT2A
SCHEMBL31648510 0.86 MAPT (0.82) ALDH1A1HTTPKMMAPTKMT2A
SCHEMBL30883296 0.84 ALDH1A1 (1.00) ALDH1A1HTTPKMMAPTKMT2A
SCHEMBL22897308 0.84 ALDH1A1 (1.00) ALDH1A1HTTPKMMAPTKMT2A
SCHEMBL2270723 0.84 ALDH1A1 (1.00) ALDH1A1HTTPKMMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10723998-B2 Application of ethyl p-methoxycinnamate and derivatives thereof in maintaining self-renewal and pluripotency of stem cells NORTHEAST NORMAL UNIVERSITY (CN) 2020-07-28 US claimed
EP-2242774-B2 SELF-REPAIRING COMPOSITION, SELF-REPAIRING MATERIALS, SELF-REPAIRING METHODS AND APPLICATIONS CATALYSE (FR) 2018-09-26 EP claimed
US-20180195039-A1 APPLICATION OF ETHYL P-METHOXYCINNAMATE AND DERIVATIVES THEREOF IN MAINTAINING SELF-RENEWAL AND PLURIPOTENCY OF STEM CELLS NORTHEAST NORMAL UNIVERSITY (CN) 2018-07-12 US claimed
EP-2242774-B1 SELF-REPAIRING COMPOSITION, SELF-REPAIRING MATERIALS, SELF-REPAIRING METHODS AND APPLICATIONS CATALYSE (FR) 2013-01-09 EP claimed
US-10723998-B2 Application of ethyl p-methoxycinnamate and derivatives thereof in maintaining self-renewal and pluripotency of stem cells NORTHEAST NORMAL UNIVERSITY (CN) 2020-07-28 US disclosed
US-20180195039-A1 APPLICATION OF ETHYL P-METHOXYCINNAMATE AND DERIVATIVES THEREOF IN MAINTAINING SELF-RENEWAL AND PLURIPOTENCY OF STEM CELLS NORTHEAST NORMAL UNIVERSITY (CN) 2018-07-12 US disclosed
US-9249237-B2 Self-repairing composition, self-repairing materials, self-repairing methods and applications CATALYSE (FR) 2016-02-02 US disclosed
US-20120202912-A1 SURFACE TREATMENT BY PHOTOPOLYMERISATION TO OBTAIN BIOCIDAL PROPERTIES DESARROLLO DEL GRAFTING S.L. (ES) 2012-08-09 US disclosed
US-20110057340-A1 SELF-REPAIRING COMPOSITION, SELF-REPAIRING MATERIALS, SELF-REPAIRING METHODS AND APPLICATIONS CATALYSE (FR) 2011-03-10 US disclosed
US-20050095266-A1 Surface treatment by photopolymerisation to obtain biocidal properties DESARROLLO DEL GRAFTING S.L. (ES) 2005-05-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180195039-A1 APPLICATION OF ETHYL P-METHOXYCINNAMATE AND DERIVATIVES THEREOF IN MAINTAINING SELF-RENEWAL AND PLURIPOTENCY OF STEM CELLS XPA, MEP1A, EED ALDH1A1 107/4885HTT 3784/4885PKM 2068/4885
US-10723998-B2 Application of ethyl p-methoxycinnamate and derivatives thereof in maintaining self-renewal and pluripotency of stem cells XPA, MEP1A, EED ALDH1A1 107/4885HTT 3784/4885PKM 2068/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.