Sugi Predict

Sugi Predict / Compounds / SCHEMBL21385602

SCHEMBL21385602

SCHEMBL21385602

C=CC[C@]1(CO[Si](C)(C)C(C)(C)C)O[C@@H](n2ccc(=O)[nH]c2=O)[C@H](F)C1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.43

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ DUT P33316 3/20 0.43
▸ SLC28A1 O00337 1/20 0.31
▸ SLC28A2 O43868 1/20 0.31
▸ SLC29A1 Q99808 1/20 0.31
▸ SLC28A3 Q9HAS3 1/20 0.31
▸ P2RY6 Q15077 1/20 0.31
▸ P2RY14 Q15391 3/20 0.31
▸ P2RY2 P41231 3/20 0.31
▸ P2RY4 P51582 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19590387 0.92 DUT (0.48) DUTSLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL19993681 0.91 DUT (0.40) DUTSLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL26273674 0.88 DUT (0.45) DUTSLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL26707485 0.88 DUT (0.45) DUTSLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL25397391 0.88 DUT (0.45) DUTSLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL25401717 0.88 DUT (0.45) DUTSLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL19590315 0.87 DUT (0.31) DUT
SCHEMBL25401571 0.86 DUT (0.44) DUTSLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL26707488 0.86 DUT (0.44) DUTSLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL19590191 0.85 DUT (0.42) DUTSLC28A1SLC28A2SLC29A1SLC28A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210179656-A1 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF Janssen Biopharma, Inc. (US) 2021-06-17 — — US disclosed
US-11021509-B2 Substituted nucleosides, nucleotides and analogs thereof Janssen Biopharma, Inc. (US) 2021-06-01 — — US disclosed
US-RE48171-E1 Substituted nucleosides, nucleotides and analogs thereof Janssen Biopharma, Inc. (US) 2020-08-25 — — US disclosed
US-20200024297-A1 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF Janssen Biopharma, Inc. (US) 2020-01-23 — — US disclosed
US-10464965-B2 Substituted nucleosides, nucleotides and analogs thereof ALIOS BIOPHARMA, INC. (US) 2019-11-05 — — US disclosed
US-10420788-B2 — — 2019-09-24 — — US disclosed
US-10421771-B2 — — 2019-09-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10464965-B2 Substituted nucleosides, nucleotides and analogs thereof PNP, NT5C3B, ADAR DUT 30/4885SLC28A1 38/4885SLC28A2 47/4885
US-20200024297-A1 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF PNP, NT5C3B, ADAR DUT 30/4885SLC28A1 38/4885SLC28A2 47/4885
US-11021509-B2 Substituted nucleosides, nucleotides and analogs thereof PNP, NT5C3B, ADAR DUT 30/4885SLC28A1 38/4885SLC28A2 47/4885
US-10420788-B2 — PNP, ADAR, NT5C2 DUT 16/4885SLC28A1 104/4885SLC28A2 99/4885
US-20210179656-A1 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF PNP, NT5C3B, ADAR DUT 30/4885SLC28A1 38/4885SLC28A2 47/4885
US-10421771-B2 — PNP, ADAR, NT5C2 DUT 16/4885SLC28A1 104/4885SLC28A2 99/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.