Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA2 | O43464 | 8/20 | 0.39 |
| ▸ | HTRA1 | Q92743 | 8/20 | 0.39 |
| ▸ | ALB | P02768 | 2/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | SHC1 | P29353 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14932607 | 0.81 | HTRA2 (0.54) | HTRA2HTRA1ALBWDR5FOLH1 | |
| SCHEMBL20235710 | 0.79 | HTRA2 (0.49) | HTRA2HTRA1ALBWDR5FOLH1 | |
| SCHEMBL18220762 | 0.77 | CA12 (0.44) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL11983772 | 0.76 | CA12 (0.50) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL10315740 | 0.76 | CA12 (0.50) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL14932614 | 0.75 | HTRA2 (0.52) | HTRA2HTRA1ALBWDR5FOLH1 | |
| SCHEMBL18220760 | 0.75 | CA1 (0.47) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL20047392 | 0.74 | FOLH1 (0.51) | HTRA2HTRA1ALBWDR5FOLH1 | |
| SCHEMBL13833492 | 0.70 | HTRA2 (0.38) | HTRA2HTRA1ALBWDR5FOLH1 | |
| SCHEMBL11906012 | 0.70 | CA9 (0.46) | KDM4EALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10421778-B2 | Isoform-selective lysine deacetylase inhibitors | WASHINGTON UNIVERSITY (US) | 2019-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10421778-B2 | Isoform-selective lysine deacetylase inhibitors | DOT1L, KDM1A, HDAC1 | HTRA2 2107/4885HTRA1 2491/4885ALB 4863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.