⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21386598 | 0.72 | — | — | |
| SCHEMBL21386608 | 0.72 | GAA (0.33) | — | |
| SCHEMBL21386679 | 0.71 | — | — | |
| SCHEMBL23633030 | 0.70 | PIM1 (0.32) | — | |
| SCHEMBL23633027 | 0.70 | PIM1 (0.32) | — | |
| SCHEMBL29593184 | 0.70 | PIM1 (0.32) | — | |
| SCHEMBL30583100 | 0.68 | EGFR (0.34) | — | |
| SCHEMBL23135911 | 0.65 | KDM4E (0.31) | — | |
| SCHEMBL21386713 | 0.64 | — | — | |
| SCHEMBL23633041 | 0.63 | ALDH1A1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11008292-B2 | FGFR4 inhibitor and preparation method and use thereof | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2021-05-18 | — | — | US | disclosed |
| EP-3543227-B1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2020-12-30 | — | — | EP | disclosed |
| US-20200062716-A1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2020-02-27 | — | — | US | disclosed |
| EP-3543227-A1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | Guangdong Zhongsheng Pharmaceutical Co., Ltd (CN) | 2019-09-25 | — | — | EP | disclosed |