Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 16/20 | 0.68 |
| ▸ | EGFR | P00533 | 3/20 | 0.61 |
| ▸ | JAK3 | P52333 | 5/20 | 0.49 |
| ▸ | ITK | Q08881 | 2/20 | 0.49 |
| ▸ | HCK | P08631 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | BLK | P51451 | 2/20 | 0.48 |
| ▸ | BMX | P51813 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21386778 | 0.91 | BTK (0.66) | BTKEGFRJAK3ITKBLK | |
| SCHEMBL21386777 | 0.88 | BTK (0.75) | BTKEGFRJAK3BLK | |
| SCHEMBL21386725 | 0.88 | BTK (0.67) | BTKEGFRJAK3ITKHCK | |
| SCHEMBL18877721 | 0.86 | BTK (0.86) | BTKEGFRJAK3ITKHCK | |
| SCHEMBL14228143 | 0.86 | BTK (0.86) | BTKEGFRJAK3ITKHCK | |
| SCHEMBL21386783 | 0.85 | BTK (0.67) | BTKEGFRJAK3HCKBLK | |
| SCHEMBL19533425 | 0.84 | BTK (0.82) | BTKEGFRJAK3ITKHCK | |
| SCHEMBL19533550 | 0.84 | BTK (0.82) | BTKEGFRJAK3ITKHCK | |
| SCHEMBL21386748 | 0.84 | BTK (0.74) | BTKEGFRJAK3ITKHCK | |
| SCHEMBL21386782 | 0.84 | BTK (0.67) | BTKEGFRITKBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543239-A1 | SELECTIVE BRUTON'S TYROSINE KINASE INHIBITOR AND USE THEREOF | Hangzhou Hertz Pharmaceutical Co., Ltd. (CN) | 2019-09-25 | — | — | EP | disclosed |