Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 15/20 | 0.74 |
| ▸ | EGFR | P00533 | 4/20 | 0.66 |
| ▸ | JAK3 | P52333 | 6/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | TEC | P42680 | 3/20 | 0.47 |
| ▸ | TXK | P42681 | 2/20 | 0.47 |
| ▸ | BMX | P51813 | 2/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 2/20 | 0.47 |
| ▸ | YES1 | P07947 | 2/20 | 0.47 |
| ▸ | LYN | P07948 | 2/20 | 0.47 |
| ▸ | HCK | P08631 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | CSK | P41240 | 2/20 | 0.47 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.47 |
| ▸ | LATS1 | O95835 | 1/20 | 0.47 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18877721 | 0.91 | BTK (0.86) | BTKEGFRJAK3JAK1TEC | |
| SCHEMBL14228143 | 0.91 | BTK (0.86) | BTKEGFRJAK3JAK1TEC | |
| SCHEMBL21386777 | 0.91 | BTK (0.75) | BTKEGFRJAK3JAK1BLK | |
| SCHEMBL21386710 | 0.88 | BTK (0.68) | BTKEGFRJAK3JAK1ITK | |
| SCHEMBL21386735 | 0.87 | BTK (0.76) | BTKEGFRJAK3JAK1TEC | |
| SCHEMBL17816357 | 0.86 | BTK (0.77) | BTKEGFRTECBMXITK | |
| SCHEMBL21386782 | 0.86 | BTK (0.67) | BTKEGFRTECBMXITK | |
| SCHEMBL19533419 | 0.85 | BTK (1.00) | BTKEGFRJAK3JAK1TEC | |
| SCHEMBL19533436 | 0.85 | BTK (1.00) | BTKEGFRJAK3JAK1TEC | |
| SCHEMBL19097822 | 0.84 | BTK (0.71) | BTKEGFRJAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543239-A1 | SELECTIVE BRUTON'S TYROSINE KINASE INHIBITOR AND USE THEREOF | Hangzhou Hertz Pharmaceutical Co., Ltd. (CN) | 2019-09-25 | — | — | EP | disclosed |