Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | QPCT | Q16769 | 5/20 | 0.33 |
| ▸ | QPCTL | Q9NXS2 | 3/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22901539 | 0.85 | KDM4E (0.40) | BRD4CREBBPKDM4EMAPTALDH1A1 | |
| SCHEMBL21565693 | 0.83 | KDM5B (0.37) | BRD4CREBBPKDM4EMAPTALDH1A1 | |
| SCHEMBL21387779 | 0.78 | QPCT (0.38) | BRD4CREBBPKDM4EMAPTALDH1A1 | |
| SCHEMBL21373612 | 0.77 | BRD4 (0.35) | BRD4CREBBPKDM4EMAPTALDH1A1 | |
| SCHEMBL31143361 | 0.76 | MAPT (0.50) | BRD4CREBBPKDM4EMAPTALDH1A1 | |
| SCHEMBL6008269 | 0.76 | MAPT (0.50) | BRD4CREBBPKDM4EMAPTALDH1A1 | |
| SCHEMBL21387783 | 0.75 | BRD4 (0.38) | BRD4CREBBPKDM4EMAPTALDH1A1 | |
| SCHEMBL13373486 | 0.74 | PARP1 (0.46) | BRD4CREBBPKDM4EMAPTALDH1A1 | |
| SCHEMBL21565690 | 0.71 | QPCT (0.36) | BRD4CREBBPKDM4EMAPTALDH1A1 | |
| SCHEMBL21565697 | 0.71 | KDM5B (0.37) | BRD4CREBBPKDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3568133-B1 | CELL-PROTECTIVE COMPOUNDS AND THEIR USE | ETH ZUERICH (CH) | 2023-12-13 | — | — | EP | disclosed |
| WO-2019179890-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH ZURICH (CH) | 2019-09-26 | — | — | WO | disclosed |
| EP-3543231-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH Zurich (CH) | 2019-09-25 | — | — | EP | disclosed |