Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | EDNRB | P24530 | 4/20 | 0.46 |
| ▸ | EDNRA | P25101 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21565630 | 0.91 | SMN1; SMN2 (0.50) | SMN1; SMN2TSHRLMNAMAPTKDM4E | |
| SCHEMBL21387721 | 0.89 | THRB (0.48) | SMN1; SMN2TSHRLMNAMAPTKDM4E | |
| SCHEMBL20386134 | 0.80 | TSHR (0.55) | SMN1; SMN2TSHRLMNAMAPTKDM4E | |
| SCHEMBL30501034 | 0.80 | TSHR (0.55) | SMN1; SMN2TSHRLMNAMAPTKDM4E | |
| SCHEMBL28331420 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2TSHRLMNAMAPTKDM4E | |
| SCHEMBL28330093 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2TSHRLMNAMAPTKDM4E | |
| SCHEMBL21381476 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2TSHRLMNAMAPTKDM4E | |
| SCHEMBL30501032 | 0.72 | SMN1; SMN2 (0.55) | SMN1; SMN2TSHRLMNAMAPTKDM4E | |
| SCHEMBL20386120 | 0.72 | SMN1; SMN2 (0.55) | SMN1; SMN2TSHRLMNAMAPTKDM4E | |
| SCHEMBL20379069 | 0.70 | LMNA (0.53) | SMN1; SMN2TSHRLMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543231-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH Zurich (CH) | 2019-09-25 | — | — | EP | disclosed |