Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | CCR4 | P51679 | 1/20 | 0.30 |
| ▸ | LDHA | P00338 | 1/20 | 0.30 |
| ▸ | LDHB | P07195 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3018852 | 0.83 | CRHR1 (0.38) | ADORA3ADORA2AADORA2BADORA1ATR | |
| SCHEMBL20607670 | 0.77 | TLR8 (0.47) | ATRCCR4LDHALDHB | |
| SCHEMBL4054099 | 0.75 | EGFR (0.48) | LDHALDHB | |
| SCHEMBL4064799 | 0.75 | EGFR (0.48) | LDHALDHB | |
| SCHEMBL3956498 | 0.75 | EGFR (0.48) | LDHALDHB | |
| SCHEMBL28104016 | 0.74 | PDE10A (0.40) | ATRCCR4 | |
| SCHEMBL20607669 | 0.73 | CDK1 (0.35) | ATR | |
| SCHEMBL31471043 | 0.71 | CRHR1 (0.41) | ADORA3ADORA2AADORA2BADORA1CCR4 | |
| SCHEMBL7322176 | 0.71 | ADORA2A (0.37) | ADORA2AATRCCR4 | |
| SCHEMBL30588876 | 0.71 | ADORA2A (0.37) | ADORA2AATRCCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2995619-B1 | CERTAIN CHEMICAL ENTITIES COMPRISING IMIDAZOPYRIMIDINES, COMPOSITIONS AND METHODS | CYTOKINETICS INC (US) | 2019-09-25 | — | — | EP | disclosed |