SCHEMBL2138934

SCHEMBL2138934

O=C(NCCC(OCc1ccccc1)C(=O)O)OCc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ SLC1A3 P43003 1/20 0.61
▸ SLC1A1 P43005 1/20 0.61
▸ LMNA P02545 1/20 0.60
▸ SMN1; SMN2 Q16637 1/20 0.60
▸ HTT P42858 1/20 0.57
▸ L3MBTL1 Q9Y468 2/20 0.53
▸ FOLH1 Q04609 4/20 0.52
▸ TGM2 P21980 1/20 0.51
▸ KEAP1 Q14145 2/20 0.50
▸ NFE2L2 Q16236 2/20 0.50
▸ MMP2 P08253 1/20 0.49
▸ MMP9 P14780 1/20 0.49
▸ MAPT P10636 1/20 0.49
▸ DPP8 Q6V1X1 1/20 0.47
▸ DPP7 Q9UHL4 1/20 0.47
▸ MEN1 O00255 1/20 0.47
▸ KMT2A Q03164 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2138927 1.00 SLC1A3 (0.61) SLC1A3SLC1A1LMNASMN1; SMN2HTT
SCHEMBL2141425 1.00 SLC1A3 (0.61) SLC1A3SLC1A1LMNASMN1; SMN2HTT
SCHEMBL2142681 0.92 HTT (0.62) SLC1A3SLC1A1LMNASMN1; SMN2HTT
SCHEMBL2142677 0.92 HTT (0.62) SLC1A3SLC1A1LMNASMN1; SMN2HTT
SCHEMBL2141943 0.91 FOLH1 (0.61) SLC1A3SLC1A1LMNASMN1; SMN2HTT
SCHEMBL2141938 0.91 FOLH1 (0.61) SLC1A3SLC1A1LMNASMN1; SMN2HTT
SCHEMBL13902998 0.86 LMNA (0.54) SLC1A3SLC1A1LMNASMN1; SMN2HTT
SCHEMBL11455100 0.85 SLC1A3 (0.57) SLC1A3SLC1A1LMNASMN1; SMN2HTT
SCHEMBL1336737 0.84 SLC1A3 (0.56) SLC1A3SLC1A1LMNASMN1; SMN2HTT
SCHEMBL1336735 0.84 SLC1A3 (0.56) SLC1A3SLC1A1LMNASMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4486753-B1 BROAD SPECTRUM AMINOGLYCOSIDES AND USES THEREOF REVAGENIX INC (US) 2026-05-13 — — EP disclosed
EP-4486753-A1 BROAD SPECTRUM AMINOGLYCOSIDES AND USES THEREOF Revagenix, Inc. (US) 2025-01-08 — — EP disclosed
WO-2023166488-A1 BROAD SPECTRUM AMINOGLYCOSIDES AND USES THEREOF REVAGENIX, INC. (US) 2023-09-07 — — WO disclosed
US-20160152653-A1 NOVEL AMINOGLYCOSIDE ANTIBIOTICS MEIJI SEIKA PHARMA CO LTD (JP) 2016-06-02 — — US disclosed
US-9260465-B2 Aminoglycoside antibiotics MEIJI SEIKA PHARMA CO., LTD. (JP) 2016-02-16 — — US disclosed
CN-102942603-B New aminoglycoside antibiotics MEIJI SEIKA PHARMA CO., LTD. (JP) 2016-01-20 — — CN disclosed
EP-2036917-B1 NOVEL AMINOGLYCOSIDE ANTIBIOTIC MEIJI SEIKA PHARMA CO LTD (JP) 2015-10-07 — — EP disclosed
US-20130345411-A1 NOVEL AMINOGLYCOSIDE ANTIBIOTICS MICROBIAL CHEMISTRY RESEARCH FOUNDATION (JP) 2013-12-26 — — US disclosed
US-8541394-B2 Aminoglycoside antibiotics MEIJI SEIKA PHARMA CO., LTD. (JP) 2013-09-24 — — US disclosed
US-20120165283-A1 NOVEL AMINOGLYCOSIDE ANTIBIOTICS KOBAYASHI YOSHIHIKO (JP) 2012-06-28 — — US disclosed
US-8148504-B2 Aminoglycoside antibiotics MEIJI SEIKA PHARMA CO., LTD. (JP) 2012-04-03 — — US disclosed
US-20090186841-A1 Novel aminoglycoside antibiotics MEIJI SEIKA PHARMA CO., LTD. (JP) 2009-07-23 — — US disclosed
EP-2036917-A1 NOVEL AMINOGLYCOSIDE ANTIBIOTIC MEIJI SEIKA KAISHA LTD. (JP) 2009-03-18 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130345411-A1 NOVEL AMINOGLYCOSIDE ANTIBIOTICS ATP6V1B1, REN, NRDC SLC1A3 3337/4885SLC1A1 3124/4885LMNA 2792/4885
US-20120165283-A1 NOVEL AMINOGLYCOSIDE ANTIBIOTICS ATP6V1B1, REN, NRDC SLC1A3 3337/4885SLC1A1 3124/4885LMNA 2792/4885
US-20160152653-A1 NOVEL AMINOGLYCOSIDE ANTIBIOTICS ATP6V1B1, REN, NRDC SLC1A3 3337/4885SLC1A1 3124/4885LMNA 2792/4885
US-20090186841-A1 Novel aminoglycoside antibiotics ATP6V1B1, REN, NRDC SLC1A3 3337/4885SLC1A1 3124/4885LMNA 2792/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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