Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2140271 | 0.88 | NFKB1 (0.58) | NFKB1NFKB2RELAKITADRB2 | |
| SCHEMBL2135587 | 0.88 | NFKB1 (0.61) | NFKB1NFKB2RELAADRB2ADRB1 | |
| SCHEMBL2134914 | 0.87 | NFKB1 (0.57) | NFKB1NFKB2RELAKITSCN9A | |
| SCHEMBL14050744 | 0.85 | NFKB1 (0.43) | NFKB1NFKB2RELASCN9AGSK3B | |
| SCHEMBL5079264 | 0.77 | NFKB1 (0.61) | NFKB1NFKB2RELAKITHTR2C | |
| SCHEMBL460244 | 0.76 | NFKB1 (0.58) | NFKB1NFKB2RELAKITHTR2C | |
| SCHEMBL2136321 | 0.76 | NFKB1 (0.89) | NFKB1NFKB2RELAKITHTR2C | |
| SCHEMBL13908867 | 0.75 | NFKB1 (0.81) | NFKB1NFKB2RELAKITHTR2C | |
| SCHEMBL2139370 | 0.74 | NFKB1 (1.00) | NFKB1NFKB2RELAKITHTR2C | |
| SCHEMBL30316128 | 0.74 | NFKB1 (1.00) | NFKB1NFKB2RELAKITHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110052532-A1 | Pharmaceutical composition comprising a cytokine | STROBL STEFAN | 2011-03-03 | — | — | US | disclosed |
| US-20110052532-A1 | Pharmaceutical composition comprising a cytokine | STROBL STEFAN | 2011-03-03 | — | — | US | disclosed |
| US-20110052532-A1 | Pharmaceutical composition comprising a cytokine | STROBL STEFAN | 2011-03-03 | — | — | US | disclosed |
| EP-1977759-A1 | Pharmaceutical composition comprising a cytokine | 4SC AG (DE) | 2008-10-08 | — | — | EP | disclosed |
| EP-1977759-A1 | Pharmaceutical composition comprising a cytokine | 4SC AG (DE) | 2008-10-08 | — | — | EP | disclosed |
| US-20080241100-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A CYTOKINE | 4SC AG (DE) | 2008-10-02 | — | — | US | disclosed |
| US-20080241100-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A CYTOKINE | 4SC AG (DE) | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110052532-A1 | Pharmaceutical composition comprising a cytokine | IL2, IL17A, IFNG | NFKB1 348/4885NFKB2 161/4885RELA 616/4885 |
| US-20080241100-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A CYTOKINE | IL2, IL17A, IFNG | NFKB1 348/4885NFKB2 161/4885RELA 616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.