SCHEMBL21390594

SCHEMBL21390594

c1cnc2cc(-c3ccc4ccc(-c5ccc6ncccc6n5)nc4n3)ccc2c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 6/20 0.45
RAB9A P51151 5/20 0.45
POLB P06746 1/20 0.45
ALDH1A1 P00352 6/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
CYP1A2 P05177 2/20 0.42
CYP2C19 P33261 2/20 0.42
CASP1 P29466 1/20 0.42
CASP7 P55210 1/20 0.42
HTT P42858 1/20 0.42
NR4A2 P43354 1/20 0.42
CYP3A4 P08684 3/20 0.41
AR P10275 2/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
KDM4E B2RXH2 3/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
MAPT P10636 2/20 0.40
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21481208 0.86 ALDH1A1 (0.49) NPC1RAB9APOLBALDH1A1MEN1
SCHEMBL30938000 0.84 NPC1 (0.58) NPC1RAB9APOLBALDH1A1MEN1
SCHEMBL7914859 0.84 NPC1 (0.58) NPC1RAB9APOLBALDH1A1MEN1
SCHEMBL19732204 0.83 NPC1 (0.49) NPC1RAB9APOLBALDH1A1MEN1
SCHEMBL19705286 0.82 CYP3A4 (0.48) NPC1RAB9APOLBALDH1A1MEN1
SCHEMBL19557551 0.82 NPC1 (0.45) NPC1RAB9AALDH1A1MEN1KMT2A
SCHEMBL19916545 0.81 NPC1 (0.48) NPC1RAB9APOLBALDH1A1CYP3A4
SCHEMBL21133668 0.80 NPC1 (0.58) NPC1RAB9AALDH1A1MEN1KMT2A
SCHEMBL19227053 0.80 RAB9A (0.56) NPC1RAB9APOLBALDH1A1MEN1
SCHEMBL22216966 0.79 BCHE (0.43) NPC1RAB9APOLBALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190292309-A1 HIGH POLYMER, MIXTURE CONTAINING SAME, COMPOSITION, ORGANIC ELECTRONIC COMPONENT, AND MONOMER FOR POLYMERIZATION GUANGZHOU CHINARAY OPTOELECTRONIC MATERIALS LTD. (CN) 2019-09-26 US disclosed