SCHEMBL21390732

SCHEMBL21390732

C=CCc1ccc(-c2cccc(-c3ccc(-c4cccc(-c5cccc(-c6nc(-c7ccncc7)nc(-c7ccncc7)n6)c5)c4)cc3)c2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCI P41743 1/20 0.43
CYP17A1 P05093 9/20 0.42
CYP11B1 P15538 9/20 0.42
CYP11B2 P19099 9/20 0.42
CYP3A4 P08684 6/20 0.42
CYP19A1 P11511 5/20 0.42
PRMT6 Q96LA8 1/20 0.40
MAPT P10636 3/20 0.39
PTGS2 P35354 1/20 0.39
GAA P10253 1/20 0.37
NPC1 O15118 1/20 0.37
NFKB1 P19838 1/20 0.37
RAB9A P51151 1/20 0.37
NFKB2 Q00653 1/20 0.37
RELA Q04206 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
HSD17B10 Q99714 1/20 0.37
KIF11 P52732 1/20 0.36
HRH3 Q9Y5N1 1/20 0.36
AURKA O14965 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21390642 1.00 PRKCI (0.43) PRKCICYP17A1CYP11B1CYP11B2CYP3A4
SCHEMBL21390737 0.96 MAPT (0.41) PRKCICYP17A1CYP11B1CYP11B2CYP3A4
SCHEMBL21390739 0.88 PTGS2 (0.43) CYP3A4MAPTPTGS2SMN1; SMN2
SCHEMBL21390634 0.86 CYP2A6 (0.48) CYP17A1CYP11B1CYP11B2CYP19A1PRMT6
SCHEMBL21390741 0.86 CYP2A6 (0.48) CYP17A1CYP11B1CYP11B2CYP19A1PRMT6
SCHEMBL21390285 0.85 PRKCI (0.47) PRKCICYP11B1CYP11B2PRMT6MAPT
SCHEMBL21390636 0.84 CYP2A6 (0.46) CYP17A1CYP11B1CYP11B2CYP3A4CYP19A1
SCHEMBL21390641 0.83 IDH1 (0.43) MAPTPTGS2GAASMN1; SMN2
SCHEMBL21390585 0.83 IDH1 (0.43) MAPTPTGS2GAASMN1; SMN2
SCHEMBL21390740 0.83 CYP19A1 (0.44) CYP17A1CYP11B1CYP11B2CYP3A4CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190292309-A1 HIGH POLYMER, MIXTURE CONTAINING SAME, COMPOSITION, ORGANIC ELECTRONIC COMPONENT, AND MONOMER FOR POLYMERIZATION GUANGZHOU CHINARAY OPTOELECTRONIC MATERIALS LTD. (CN) 2019-09-26 US disclosed