Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 9/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 9/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCND3 | P30281 | 1/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21390672 | 0.90 | BRD4 (0.34) | BRD4CREBBPACACBCDK4CCND1 | |
| SCHEMBL23132029 | 0.84 | HDAC1 (0.33) | BRD4CREBBPCDK4CCND1CCND3 | |
| SCHEMBL21391103 | 0.84 | HDAC1 (0.33) | BRD4CREBBPCDK4CCND1CCND3 | |
| SCHEMBL21390898 | 0.84 | HDAC1 (0.32) | CDK4CCND1CCND3CDK6HDAC1 | |
| SCHEMBL21390933 | 0.83 | CDK4 (0.32) | CDK4CCND1CCND3CDK6HDAC1 | |
| SCHEMBL21390697 | 0.83 | BRD4 (0.33) | BRD4CREBBPACACBCDK4CCND1 | |
| SCHEMBL21390935 | 0.82 | HDAC1 (0.33) | BRD4CREBBPCDK4CCND1CCND3 | |
| SCHEMBL21391027 | 0.80 | CDK4 (0.32) | CDK4CCND1CCND3CDK6HDAC1 | |
| SCHEMBL21390822 | 0.79 | CYP19A1 (0.33) | CDK4CCND1CCND3CDK6HDAC1 | |
| SCHEMBL21354610 | 0.78 | CACNA1H (0.40) | CACNA1HBRD4CREBBPMAPK1ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |