Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 11/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30315414 | 0.81 | TRPV4 (0.43) | CYP11B2CYP11B1TRPV4 | |
| SCHEMBL21354747 | 0.81 | TRPV4 (0.43) | CYP11B2CYP11B1TRPV4 | |
| SCHEMBL21390800 | 0.78 | TRPV4 (0.39) | CYP11B2CYP11B1HDAC1TRPV4 | |
| SCHEMBL21390959 | 0.78 | TRPV4 (0.39) | CYP11B2CYP11B1HDAC1TRPV4 | |
| SCHEMBL30659123 | 0.76 | ALK (0.43) | CYP11B2CYP11B1TRPV4 | |
| SCHEMBL17582997 | 0.76 | ALK (0.43) | CYP11B2CYP11B1TRPV4 | |
| SCHEMBL17583002 | 0.76 | ALK (0.43) | CYP11B2CYP11B1TRPV4 | |
| SCHEMBL21580940 | 0.75 | TRPV4 (0.42) | CYP11B2CYP11B1TRPV4 | |
| SCHEMBL21391007 | 0.74 | CYP11B2 (0.42) | CYP11B2CYP11B1HDAC1TRPV4 | |
| SCHEMBL23132031 | 0.74 | CYP11B2 (0.41) | CYP11B2CYP11B1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |