Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 11/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21390959 | 1.00 | TRPV4 (0.39) | TRPV4CYP11B2CYP11B1IDH1ADRB1 | |
| SCHEMBL18792015 | 0.81 | TRPV4 (0.47) | TRPV4CYP11B2ALK | |
| SCHEMBL18791668 | 0.81 | TRPV4 (0.47) | TRPV4CYP11B2ALK | |
| SCHEMBL20111282 | 0.81 | TRPV4 (0.47) | TRPV4CYP11B2ALK | |
| SCHEMBL21390801 | 0.81 | PTGDR2 (0.36) | TRPV4CYP11B2CYP11B1IDH1 | |
| SCHEMBL21390669 | 0.79 | CYP11B2 (0.39) | CYP11B2CYP11B1CYP19A1ALKHDAC1 | |
| SCHEMBL21391034 | 0.79 | TNKS (0.32) | HDAC1 | |
| SCHEMBL21391155 | 0.79 | ACSS2 (0.39) | CYP11B2CYP11B1HDAC1 | |
| SCHEMBL21390805 | 0.78 | TNKS (0.35) | HDAC1 | |
| SCHEMBL21390970 | 0.78 | CYP11B2 (0.38) | TRPV4CYP11B2CYP11B1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |