Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 8/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.41 |
| ▸ | CDK4 | P11802 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.36 |
| ▸ | PDE6D | O43924 | 1/20 | 0.35 |
| ▸ | PDE6A | P16499 | 1/20 | 0.35 |
| ▸ | PDE6G | P18545 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE6B | P35913 | 1/20 | 0.35 |
| ▸ | PDE6C | P51160 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | CDK7 | P50613 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21390939 | 0.86 | PDE2A (0.41) | PDE2APDE10ACDK4CDK2CDK6 | |
| SCHEMBL21391015 | 0.81 | CDK4 (0.37) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL21354616 | 0.74 | KCNQ2 (0.38) | PDE2APDE10ACDK4CDK2CDK9 | |
| SCHEMBL21354655 | 0.72 | CACNA1H (0.33) | CDK4CDK2CDK9CCNA2 | |
| SCHEMBL21391183 | 0.72 | CYP11B2 (0.46) | PDE2APDE10ACDK4CDK2CDK6 | |
| SCHEMBL21390922 | 0.70 | ALOX5AP (0.31) | — | |
| SCHEMBL18202603 | 0.69 | CDK4 (0.37) | CDK4CDK2CDK6CDK1CDK7 | |
| SCHEMBL23329845 | 0.69 | CACNA1H (0.32) | PDE2APDE10ATRPC6 | |
| SCHEMBL23329945 | 0.67 | CACNA1H (0.31) | PDE2APDE10ATRPC6 | |
| SCHEMBL21390698 | 0.65 | PDE10A (0.32) | PDE2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |