Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 6/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.40 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18202584 | 0.81 | CCNT1 (0.47) | CYP11B2CYP11B1MAPK1CCNT1CDK9 | |
| SCHEMBL21390699 | 0.80 | HRH3 (0.42) | CYP11B2CCNT1CDK9PDE10ACDK4 | |
| SCHEMBL15252331 | 0.78 | CDK9 (0.50) | CYP11B2CYP11B1MAPK1CCNT1CDK9 | |
| SCHEMBL30039369 | 0.74 | CCNT1 (0.42) | CYP11B2CYP11B1MAPK1CCNT1CDK9 | |
| SCHEMBL15252582 | 0.74 | CCNT1 (0.42) | CYP11B2CYP11B1MAPK1CCNT1CDK9 | |
| SCHEMBL21354610 | 0.74 | CACNA1H (0.40) | MAPK1ALDH1A1 | |
| SCHEMBL21017336 | 0.73 | CCNT1 (0.44) | CYP11B2CYP11B1MAPK1CCNT1CDK9 | |
| SCHEMBL18202581 | 0.73 | CCNT1 (0.40) | CYP11B2CYP11B1MAPK1CCNT1CDK9 | |
| SCHEMBL19836553 | 0.72 | CYP11B2 (0.43) | CYP11B2CYP11B1MAPK1CCNT1CDK9 | |
| SCHEMBL21391081 | 0.72 | PDE2A (0.41) | CDK9PDE2APDE10ACDK4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |