Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 4/20 | 0.34 |
| ▸ | CDK4 | P11802 | 3/20 | 0.33 |
| ▸ | CCND1 | P24385 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
| ▸ | CCND3 | P30281 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21390950 | 0.82 | CYP11B2 (0.36) | RORCJAK1HDAC1 | |
| SCHEMBL21390774 | 0.80 | RORC (0.41) | RORCJAK1CDK4CCND1JAK2 | |
| SCHEMBL21391120 | 0.79 | TBXA2R (0.35) | TBXA2RRORCJAK1JAK2 | |
| SCHEMBL21391130 | 0.77 | CYP11B2 (0.38) | HDAC1 | |
| SCHEMBL16084157 | 0.77 | TBXA2R (0.38) | TBXA2RCDK4CCND1HDAC1PLA2G1B | |
| SCHEMBL21390755 | 0.76 | RORC (0.40) | RORCCDK4CCND1 | |
| SCHEMBL21390880 | 0.74 | HDAC1 (0.37) | RORCHDAC1 | |
| SCHEMBL21390815 | 0.74 | HDAC1 (0.33) | RORCJAK1HDAC1 | |
| SCHEMBL21390892 | 0.74 | KDM4E (0.33) | JAK1JAK2 | |
| SCHEMBL17481359 | 0.73 | TBXA2R (0.34) | TBXA2RJAK1CDK4CCND1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |