SCHEMBL2139169

SCHEMBL2139169

C=Cc1c(NCc2ccco2)cc(-c2ccc(Cl)c(N(C)C)c2F)nc1C(=O)OC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 6/20 0.42
AQP1 P29972 1/20 0.39
ALDH1A1 P00352 7/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
PKM P14618 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.36
TEX264 Q9Y6I9 1/20 0.36
RECQL P46063 1/20 0.36
CTDSP1 Q9GZU7 1/20 0.36
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
HTR1A P08908 1/20 0.35
CA4 P22748 1/20 0.35
CA6 P23280 1/20 0.35
HSD11B1 P28845 1/20 0.35
CA5A P35218 1/20 0.35
CA7 P43166 1/20 0.35
SLC10A1 Q14973 1/20 0.35
CA9 Q16790 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2140353 0.90 APP (0.43) APPAQP1ALDH1A1PKML3MBTL1
SCHEMBL2136110 0.90 APP (0.43) APPAQP1ALDH1A1SMN1; SMN2PKM
SCHEMBL10087223 0.87 ALDH1A1 (0.37) APPAQP1ALDH1A1SMN1; SMN2PKM
SCHEMBL10206317 0.81 APP (0.45) APPAQP1ALDH1A1SMN1; SMN2PKM
SCHEMBL2138077 0.80 APP (0.42) APPAQP1ALDH1A1SMN1; SMN2PKM
SCHEMBL11902544 0.80 APP (0.42) APPAQP1ALDH1A1SMN1; SMN2PKM
SCHEMBL2138062 0.80 APP (0.42) APPAQP1ALDH1A1SMN1; SMN2PKM
SCHEMBL2136872 0.79 APP (0.50) APPAQP1ALDH1A1SMN1; SMN2CA12
SCHEMBL2137670 0.79 APP (0.44) APPAQP1ALDH1A1PKML3MBTL1
SCHEMBL12786051 0.79 APP (0.44) APPAQP1ALDH1A1SMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2445884-B1 4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES SYNGENTA LTD (GB) 2013-02-13 EP disclosed
US-20120100990-A1 4 -AMINOPICOLINATES AND THEIR USE AS HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-04-26 US disclosed
US-20120100990-A1 4 -AMINOPICOLINATES AND THEIR USE AS HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-04-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120100990-A1 4 -AMINOPICOLINATES AND THEIR USE AS HERBICIDES DDT, DAO, NPM1 APP 2550/4885AQP1 1271/4885ALDH1A1 1297/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.