Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTPS1 | P17812 | 14/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21392001 | 0.87 | CTPS1 (0.41) | CTPS1WNT3A | |
| SCHEMBL21392038 | 0.78 | MAPT (0.35) | SMN1; SMN2MAPTKDM4E | |
| SCHEMBL23121032 | 0.78 | CTPS1 (0.51) | CTPS1 | |
| SCHEMBL29566569 | 0.78 | CTPS1 (0.51) | CTPS1 | |
| SCHEMBL21392334 | 0.73 | CTPS1 (0.50) | CTPS1 | |
| SCHEMBL29489085 | 0.72 | CTPS1 (0.52) | CTPS1 | |
| SCHEMBL29086297 | 0.72 | CTPS1 (0.52) | CTPS1 | |
| SCHEMBL21392292 | 0.72 | ALDH1A1 (0.35) | MAPTKDM4EALDH1A1 | |
| SCHEMBL21392153 | 0.71 | CTPS1 (0.45) | CTPS1WNT3A | |
| SCHEMBL24832439 | 0.71 | CTPS1 (0.59) | CTPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019179652-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | STEP PHARMA S.A.S. (FR) | 2019-09-26 | — | — | WO | disclosed |