Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ASPH | Q12797 | 1/20 | 0.33 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MLYCD | O95822 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22762439 | 0.84 | LMNA (0.33) | MAPTUSP2TSHRLMNA | |
| SCHEMBL21392292 | 0.83 | ALDH1A1 (0.35) | MAPTUSP2TSHRKDM4EASPH | |
| SCHEMBL29047788 | 0.81 | TRPM8 (0.37) | TRPM8TAS2R14PTGES | |
| SCHEMBL21392335 | 0.81 | MLYCD (0.35) | MAPTSMN1; SMN2KDM4ELMNAMLYCD | |
| SCHEMBL21392148 | 0.81 | LMNA (0.33) | MAPTUSP2TSHRTAS2R14PTGES | |
| SCHEMBL21392076 | 0.79 | MLYCD (0.33) | MAPTKDM4ELMNAMLYCD | |
| SCHEMBL21392333 | 0.78 | CTPS1 (0.38) | MAPTSMN1; SMN2KDM4E | |
| SCHEMBL21392246 | 0.74 | APLNR (0.35) | SMN1; SMN2KDM4EASPHKDM8LMNA | |
| SCHEMBL21392149 | 0.73 | TRPM8 (0.38) | TRPM8TAS2R14PTGES | |
| SCHEMBL30416019 | 0.73 | TRPM8 (0.38) | TRPM8TAS2R14PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019180244-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | STEP PHARMA S.A.S. (FR) | 2019-09-26 | — | — | WO | disclosed |
| WO-2019179652-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | STEP PHARMA S.A.S. (FR) | 2019-09-26 | — | — | WO | disclosed |