SCHEMBL21392614

SCHEMBL21392614

c1ccc(-c2cc3c(cc2N(c2ccc4c(c2)C(c2ccccc2)(c2ccccc2)c2ccccc2-4)c2ccc4oc5ccccc5c4c2)C(c2ccccc2)(c2ccccc2)c2ccccc2-3)cc1

nearest known ligand 0.33

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.33
MEN1 O00255 2/20 0.33
MAPT P10636 2/20 0.33
KMT2A Q03164 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
NPC1 O15118 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
RAB9A P51151 1/20 0.33
LMNA P02545 1/20 0.32
OPRK1 P41145 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21392658 0.99 KDM4E (0.33) KDM4EMEN1MAPTKMT2ASMN1; SMN2
SCHEMBL21392496 0.95 ALK (0.33) KDM4EMEN1MAPTKMT2ASMN1; SMN2
SCHEMBL21392657 0.95 KDM4E (0.35) KDM4EMEN1MAPTKMT2ASMN1; SMN2
SCHEMBL26999828 0.94 PLA2G2A (0.33) KDM4EMEN1MAPTKMT2ASMN1; SMN2
SCHEMBL21392618 0.94 MEN1 (0.33) KDM4EMEN1MAPTKMT2ASMN1; SMN2
SCHEMBL26999829 0.93 PLA2G2A (0.32) KDM4EMEN1MAPTKMT2ASMN1; SMN2
SCHEMBL21392601 0.93 MEN1 (0.32) KDM4EMEN1MAPTKMT2ASMN1; SMN2
SCHEMBL25603739 0.92 KDM4E (0.33) KDM4EMEN1MAPTKMT2ASMN1; SMN2
SCHEMBL16996032 0.92 KDM4E (0.32) KDM4EMEN1MAPTKMT2ASMN1; SMN2
SCHEMBL21707841 0.91 KDM4E (0.33) KDM4EMEN1MAPTKMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11877509-B2 Organic light-emitting element LG CHEM, LTD. 2024-01-16 US disclosed
US-11877509-B2 Organic light-emitting element LG CHEM, LTD. 2024-01-16 US disclosed
US-20190296238-A1 Organic Light-emitting Element LG CHEM, LTD. (KR) 2019-09-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190296238-A1 Organic Light-emitting Element CRY1, CRY2, NR2E3 KDM4E 1903/4885MEN1 1414/4885MAPT 665/4885
US-11877509-B2 Organic light-emitting element CRY1, CRY2, NR2E3 KDM4E 1903/4885MEN1 1414/4885MAPT 665/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.