Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PHGDH | O43175 | 1/20 | 0.47 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | P2RY12 | Q9H244 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GPX4 | P36969 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27829814 | 0.85 | PHGDH (0.51) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL14735155 | 0.84 | PHGDH (0.50) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL2119358 | 0.83 | SMN1; SMN2 (0.78) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL18362064 | 0.82 | PHGDH (0.52) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL2289613 | 0.80 | KMT2A (0.61) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL2289609 | 0.79 | P2RY12 (0.47) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL3075186 | 0.79 | CNR2 (0.47) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL20348529 | 0.79 | PHGDH (0.49) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL20965429 | 0.78 | PHGDH (0.46) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL2366192 | 0.76 | MEN1 (0.55) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11666661-B2 | Methods and compounds for targeted autophagy | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-06-06 | — | — | US | disclosed |
| US-11666661-B2 | Methods and compounds for targeted autophagy | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-06-06 | — | — | US | disclosed |
| US-20210369731-A1 | COVALENT TARGETING OF E3 LIGASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2021-12-02 | — | — | US | disclosed |
| US-20190290778-A1 | METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY | FRONTIER MEDICINES CORPORATION | 2019-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190290778-A1 | METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY | ATG7, BECN1, SQSTM1 | KMT2A 3168/4885SMN1; SMN2 3721/4885ALDH1A1 4188/4885 |
| US-20210369731-A1 | COVALENT TARGETING OF E3 LIGASES | RNF114, RNF4, RNF168 | KMT2A 501/4885SMN1; SMN2 1834/4885ALDH1A1 2969/4885 |
| US-11666661-B2 | Methods and compounds for targeted autophagy | ATG7, BECN1, SQSTM1 | KMT2A 3168/4885SMN1; SMN2 3721/4885ALDH1A1 4188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.