Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13498672 | 0.85 | CHRNB2 (0.42) | TSHRLMNAMAPTMAPK1MEN1 | |
| SCHEMBL9965936 | 0.85 | USP2 (0.48) | TSHRMEN1KMT2APOLBUSP2 | |
| SCHEMBL23175599 | 0.84 | MEN1 (0.42) | TSHRMEN1KMT2APOLBUSP2 | |
| SCHEMBL13498671 | 0.82 | ACHE (0.46) | USP2CNR1 | |
| SCHEMBL17210781 | 0.82 | LMNA (0.50) | TSHRLMNAMAPTMAPK1POLB | |
| SCHEMBL9462495 | 0.82 | LMNA (0.50) | TSHRLMNAMAPTMAPK1POLB | |
| SCHEMBL17210780 | 0.82 | LMNA (0.50) | TSHRLMNAMAPTMAPK1POLB | |
| SCHEMBL29330118 | 0.81 | TSHR (0.49) | TSHRLMNAMAPTMAPK1POLB | |
| SCHEMBL13498668 | 0.81 | DPP7 (0.51) | CNR1 | |
| SCHEMBL12737485 | 0.80 | MEN1 (0.51) | MAPTMEN1KMT2AUSP2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183245-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2019-09-26 | — | — | WO | disclosed |