Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 7/20 | 0.33 |
| ▸ | NCF1 | P14598 | 2/20 | 0.32 |
| ▸ | NCK1 | P16333 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21393683 | 0.81 | ALDH1A1 (0.38) | ALDH1A1MEN1LMNATHRBBLM | |
| SCHEMBL21895421 | 0.74 | NCK1 (0.32) | PLAUBACE1NCK1 | |
| SCHEMBL21393367 | 0.73 | NQO1 (0.36) | — | |
| SCHEMBL7261717 | 0.73 | PLAU (0.40) | PLAUBACE1NCF1NCK1NOS2 | |
| SCHEMBL29749869 | 0.71 | NOS2 (0.54) | PLAUBACE1NCF1NCK1NOS2 | |
| SCHEMBL13723997 | 0.71 | NOS2 (0.54) | PLAUBACE1NCF1NCK1NOS2 | |
| SCHEMBL8181408 | 0.69 | TRIM24 (0.45) | PLAUBACE1NCF1NCK1NOS2 | |
| SCHEMBL12189339 | 0.69 | ALDH1A1 (0.44) | PLAUBACE1NCF1NCK1NOS2 | |
| SCHEMBL30023734 | 0.65 | NCF1 (0.44) | PLAUBACE1NCF1NCK1NOS2 | |
| SCHEMBL27886744 | 0.65 | BACE1 (0.44) | PLAUBACE1NCF1NCK1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019182925-A1 | OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | GENENTECH, INC. (US) | 2019-09-26 | — | — | WO | disclosed |