Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL80375 | 0.80 | TRPV4 (0.58) | TRPV4PDE9AKDM4E | |
| SCHEMBL14601371 | 0.75 | SELL (0.46) | TRPV4PDE9AKDM4E | |
| SCHEMBL14473069 | 0.74 | TRPV4 (0.46) | TRPV4KDM4E | |
| SCHEMBL20076570 | 0.74 | CES2 (0.35) | — | |
| SCHEMBL13980136 | 0.74 | HDAC1 (0.36) | — | |
| SCHEMBL24629320 | 0.72 | SELL (0.42) | KDM4E | |
| SCHEMBL16545828 | 0.71 | TRPV4 (0.43) | TRPV4PDE9AKDM4E | |
| SCHEMBL21563310 | 0.71 | TRPV4 (0.43) | TRPV4PDE9AKDM4E | |
| SCHEMBL16681130 | 0.71 | TRPV4 (0.43) | TRPV4PDE9AKDM4E | |
| SCHEMBL31531374 | 0.71 | TRPV4 (0.43) | TRPV4PDE9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019182925-A1 | OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | GENENTECH, INC. (US) | 2019-09-26 | — | — | WO | disclosed |