Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348369 | 0.87 | ATM (0.46) | ATMCYP11B2CA12CA1CA2 | |
| SCHEMBL20187531 | 0.84 | ATM (0.44) | ATMCYP11B2CA12CA1CA2 | |
| SCHEMBL13067195 | 0.81 | CYP2C9 (0.44) | CA12CA1CA2CA7CA9 | |
| SCHEMBL6921530 | 0.79 | CYP11B2 (0.35) | CYP11B2CYP3A4HPGD | |
| SCHEMBL25190713 | 0.79 | ALDH1A1 (0.49) | ATMCYP11B2CA12CA1CA2 | |
| SCHEMBL17197218 | 0.79 | CYP11B2 (0.41) | ATMCYP11B2CA12CA1CA2 | |
| SCHEMBL20187445 | 0.79 | ATM (0.43) | ATMCYP11B2CA12CA1CA2 | |
| SCHEMBL14392455 | 0.77 | HCAR2 (0.39) | ALDH1A1POLBKDM4ELMNA | |
| SCHEMBL22620862 | 0.76 | CYP11B2 (0.40) | ATMCYP11B2CA12CA1CA2 | |
| SCHEMBL24746934 | 0.75 | L3MBTL1 (0.37) | ATMCYP11B2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019182925-A1 | OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | GENENTECH, INC. (US) | 2019-09-26 | — | — | WO | disclosed |