Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CXCR2 | P25025 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.45 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | GCK | P35557 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29358571 | 1.00 | KDM4E (0.51) | KDM4ECXCR2ALDH1A1CXCR1PRKAA2 | |
| SCHEMBL29358776 | 0.88 | NPC1 (0.48) | KDM4ECXCR2ALDH1A1CXCR1GCK | |
| SCHEMBL21394624 | 0.88 | NPC1 (0.48) | KDM4ECXCR2ALDH1A1CXCR1GCK | |
| SCHEMBL21394623 | 0.86 | RAB9A (0.44) | KDM4ECXCR2ALDH1A1DEGS1GCK | |
| SCHEMBL29357089 | 0.86 | RAB9A (0.44) | KDM4ECXCR2ALDH1A1DEGS1GCK | |
| SCHEMBL21394659 | 0.85 | HDAC3 (0.45) | CXCR2ALDH1A1 | |
| SCHEMBL29356271 | 0.85 | HDAC3 (0.45) | CXCR2ALDH1A1 | |
| SCHEMBL29356935 | 0.81 | ALDH1A1 (0.48) | ALDH1A1GCKP4HTM | |
| SCHEMBL21394466 | 0.81 | ALDH1A1 (0.48) | ALDH1A1GCKP4HTM | |
| SCHEMBL9566833 | 0.79 | P4HTM (0.63) | CXCR2ALDH1A1CXCR1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118084800-A | Compounds and uses thereof | 詹森药业有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-118084801-A | Compounds and uses thereof | 詹森药业有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-112312913-B | Compounds and uses thereof | 詹森药业有限公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-114174273-A | Compounds and uses thereof | 优曼尼蒂治疗公司 | 2022-03-11 | — | — | CN | disclosed |
| CN-112312913-A | Compounds and uses thereof | 优曼尼蒂治疗公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |